Inflammasome increases muscle damage in muscular dystrophy, study finds

ScienceDaily (2010-06-01) -- In a new study, researchers demonstrate that affected muscle may directly contribute to inflammation in muscular dystrophy.

發炎直接導致肌肉萎縮

To investigate the role of the inflammasome, which is responsible for activation of inflammatory processes, in muscular dystrophy, Rawat et al examined the inflammasome platform in mouse and human tissues that develop limb girdle muscular dystrophy type 2B (LGMD2B). They found that components of the inflammasome pathway were upregulated and activated in diseased muscle as compared with control muscle and that primary skeletal muscle cells can secrete inflammatory mediators, directly participating in inflammasome formation. Moreover, diseased muscle cells expressed innate immune molecules, suggesting that affected muscle may directly contribute to inflammation in muscular dystrophy and providing a new therapeutic target for LGMD2B.


muscular dystrophy肌肉萎縮
inflammation 發炎；炎症