Better animal-free test for chemicals that can cause contact dermatitis

ScienceDaily (2010-06-01) -- Scientists are reporting development of a fast, simple, inexpensive method for determining whether chemicals in consumer products and workplaces may cause skin allergies in people -- a method that does not involve use of animals.

不需動物的實驗, 人體皮膚是否會過敏....

現存的化學藥劑檢測使用的物有: glutathione 會類似皮膚蛋白質, 且與致敏物結合.
但科學家稱, 早期的皮膚敏感試驗皆不合適.

本研究的皮膚蛋白質替代物質為nitrobenzenethiol : 與皮膚過敏源比較, 此化合物極合適screen基本的致敏物質.

Journal Reference:
Itai Chipinda, Risikat O. Ajibola, Moshood K. Morakinyo, Tinashe B. Ruwona, Reuben H. Simoyi, Paul D. Siegel. Rapid and Simple Kinetics Screening Assay for Electrophilic Dermal Sensitizers Using Nitrobenzenethiol. Chemical Research in Toxicology, 2010; 23 (5): 918 DOI: 10.1021/tx100003w